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Article

Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010

Jones Dallas C, Schweitzer Michelle N, Wein Marc, Sigrist Kirsten, Takagi Tsuyoshi, Ishii Shunsuke, Glimcher Laurie H

Abstract excerpt

Formation and remodeling of the skeleton relies on precise temporal and spatial regulation of genes expressed in cartilage and bone cells. Debilitating diseases of the skeletal system occur when mutations arise that disrupt these intricate genetic regulatory programs. Here, we report that mice bearing parallel null mutations in the adapter proteins Schnurri2 (Shn2) and Schnurri3 (Shn3) exhibit defects in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20404140
DOI: 10.1073/pnas.1003727107
PMCID: PMC2889532

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