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Article

Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy

9 May 2012

Abstract excerpt

Chemotherapy with alkylating agents for treating malignant disease results in myelosuppression that can significantly limit dose escalation and potential clinical efficacy. Gene therapy using mutant methylguanine methyltransferase (P140K) gene-modified hematopoietic stem and progenitor cells may circumvent this problem by abrogating the toxic effects of chemotherapy on hematopoietic cells. However, this approach...

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PMID: 22572881
DOI: 10.1126/scitranslmed.3003425

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