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Article

Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy.

Human gene therapy - 1 Jun 2011

Giordano Frank A, Sorg Ursula R, Appelt Jens-Uwe, Lachmann Nico, Bleier Stephanie, Roeder Ingo, Kleff Veronika, Flasshove Michael, Zeller W Jens, Allgayer Heike, von Kalle Christof, Fruehauf Stefan, Moritz Thomas, Laufs Stephanie

Abstract excerpt

Gene transfer of mutant O(6)-methylguanine-DNA-methyltransferase (MGMT(P140K)) into hematopoietic stem cells (HSCs) protects hematopoiesis from alkylating agents and allows efficient in vivo selection of transduced HSCs. However, insertional mutagenesis, high regenerative stress associated with selection, and the genotoxic potential of alkylating drugs represent considerable risk factors for clinical applications...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21319998
DOI: 10.1089/hum.2010.088

Genes

MGMT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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