Variations in the APP gene promoter region and risk of Alzheimer disease.

doi:10.1212/01.wnl.0000255938.33739.46

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Variations in the APP gene promoter region and risk of Alzheimer disease.

Neurology - 27 Feb 2007

Guyant-Maréchal L, Rovelet-Lecrux A, Goumidi L, Cousin E, Hannequin D, Raux G, Penet C, Ricard S, Macé S, Amouyel P, Deleuze J-F, Frebourg T, Brice A, Lambert J-C, Campion D

Abstract excerpt

We genotyped five polymorphisms, including two polymorphisms with known effects on transcriptional activity, in a large cohort of 427 Alzheimer disease (AD) cases and 472 control subjects. An association between rs463946 (-3102 G/C) and AD was found and was confirmed in a replication sample of a similar size. By contrast, analysis of three recently described rare mutations influencing APP transcription did not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Biomarkers, Tumor

Share to France

Share to Genetic Testing

Share to Incidence

Share to Receptors, Cell Surface

Share to Risk Assessment

Source

Open in PubMed

Identifiers

PMID: 17325276
DOI: 10.1212/01.wnl.0000255938.33739.46

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variations in the APP gene promoter region and risk of Alzheimer disease.PMID 17325276Read ↗

Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's diseaseSemantic proximity Read ↗

Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease.Semantic proximity Read ↗

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.Semantic proximity Read ↗

Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease.Semantic proximity Read ↗

Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.Semantic proximity Read ↗

Functional characterization of amyloid beta precursor protein regulatory elements: rationale for the identification of genetic polymorphism.Semantic proximity Read ↗

The Upstream Promoter of the β-Amyloid Precursor Protein Gene (APP) Shows Differential Patterns of Methylation in Human BrainSemantic proximity Read ↗

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.Semantic proximity Read ↗

Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case-control study.Semantic proximity Read ↗

Role of common and rare APP DNA sequence variants in Alzheimer disease.Semantic proximity Read ↗

Genetic association between APP, ADAM10 gene polymorphism, and sporadic Alzheimer's disease in the Chinese population.Semantic proximity Read ↗

Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.