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Article

Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease.

PLoS genetics - 1 Jan 2012

Lang Minglin, Wang Lei, Fan Qiangwang, Xiao Guiran, Wang Xiaoxi, Zhong Yi, Zhou Bing

Abstract excerpt

The aggregation or oligomerization of amyloid-β (Aβ) peptide is thought to be the primary causative event in the pathogenesis of Alzheimer's disease (AD). Considerable in vitro evidence indicates that the aggregation/oligomerization of Aβ is promoted in the presence of Zn; however, the functional role of Zn in AD pathogenesis is still not well clarified in vivo. Zn is imported into the brain mainly through the...

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PMID: 22570624
DOI: 10.1371/journal.pgen.1002683
PMCID: PMC3343105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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