Article
In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Mar 2013
Lye Jessica C, Richards Christopher D, Dechen Kesang, Warr Coral G, Burke Richard
Abstract excerpt
Members of the ZIP (SLC39A) and ZnT (SLC30A) families of transmembrane domain proteins are predicted to transport the essential transition metal zinc across membranes, regulating cellular zinc content and distribution via uptake and efflux at the outer plasma and organellar membranes. Twenty-four ZIP and ZnT proteins are encoded in mammalian genomes, raising questions of whether all actually transport zinc,...
Topics
- Animals
- Cation Transport Proteins
- Drosophila
- Drosophila Proteins
- Eye
- Ion Transport
- Phenotype
- RNA Interference
- Up-Regulation
- Zinc