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Article

Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.

Clinical and experimental nephrology - 1 Apr 2017

de Stephanis Lucia, Bonon Anna, Varani Katia, Lanza Giovanni, Gafà Roberta, Pinton Paolo, Pema Monika, Somlo Stefan, Boletta Alessandra, Aguiari Gianluca

Abstract excerpt

BACKGROUND: ADPKD is a renal pathology caused by mutations of PKD1 and PKD2 genes, which encode for polycystin-1 (PC1) and polycystin-2 (PC2), respectively. PC1 plays an important role regulating several signal transducers, including cAMP and mTOR, which are involved in abnormal cell proliferation of ADPKD cells leading to the development and expansion of kidney cysts that are a typical hallmark of this disease....

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Source

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Identifiers

PMID: 27278932
DOI: 10.1007/s10157-016-1289-1
PMCID: PMC5496448

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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