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Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes

15 Mar 2022

Abstract excerpt

Endoplasmic reticulum (ER) stress contributes to pancreatic beta-cell apoptosis in diabetes, but the factors involved are still not fully elucidated. Growth differentiation factor 15 (GDF15) is a stress response gene and has been reported to be increased and play an important role in various diseases. However, the role of GDF15 in beta cells in the context of ER stress and diabetes is still unclear. In this...

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PMID: 35290443
DOI: 10.1210/endocr/bqac030

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