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Article

Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.

Diabetes - 1 Aug 2008

Goldsworthy Michelle, Hugill Alison, Freeman Helen, Horner Emma, Shimomura Kenju, Bogani Debora, Pieles Guido, Mijat Vesna, Arkell Ruth, Bhattacharya Shoumo, Ashcroft Frances M, Cox Roger D

Abstract excerpt

OBJECTIVES: To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion. RESEARCH DESIGN AND METHODS: Haploinsufficiency of the insulin receptor and associated mild insulin resistance has been used to sensitize an N-ethyl-N-nitrosourea (ENU) screen to identify novel mutations resulting in impaired glucose tolerance and diabetes. The new impaired...

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Identifiers

PMID: 18477811
DOI: 10.2337/db07-0337
PMCID: PMC2494690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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