Article
Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2007
Chang-Claude Jenny, Andrieu Nadine, Rookus Matti, Brohet Richard, Antoniou Antonis C, Peock Susan, Davidson Rosemarie, Izatt Louise, Cole Trevor, Noguès Catherine, Luporsi Elisabeth, Huiart Laetitia, Hoogerbrugge Nicoline, Van Leeuwen Flora E, Osorio Ana, Eyfjord Jorunn, Radice Paolo, Goldgar David E, Easton Douglas F
Abstract excerpt
BACKGROUND: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. METHODS: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. RESULTS: Breast cancer...
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