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Article

Identification of driver genes in hepatocellular carcinoma by exome sequencing.

Hepatology (Baltimore, Md.) - 1 Nov 2013

Cleary Sean P, Jeck William R, Zhao Xiaobei, Chen Kui, Selitsky Sara R, Savich Gleb L, Tan Ting-Xu, Wu Michael C, Getz Gad, Lawrence Michael S, Parker Joel S, Li Jinyu, Powers Scott, Kim Hyeja, Fischer Sandra, Guindi Maha, Ghanekar Anand, Chiang Derek Y

Abstract excerpt

UNLABELLED: Genetic alterations in specific driver genes lead to disruption of cellular pathways and are critical events in the instigation and progression of hepatocellular carcinoma (HCC). As a prerequisite for individualized cancer treatment, we sought to characterize the landscape of recurren...

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Topics

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Intracellular Signaling Peptides and Proteins

Share to Kelch-Like ECH-Associated Protein 1

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Share to NF-E2-Related Factor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 23728943
DOI: 10.1002/hep.26540
PMCID: PMC3830584

Genes

KEAP1
CTNNB1
RAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23728943-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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