Article
Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.
PloS one - 7 May 2008
Todi Sokol V, Sivan-Loukianova Elena, Jacobs Julie S, Kiehart Daniel P, Eberl Daniel F
Abstract excerpt
BACKGROUND: Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition [1]-[5]. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called stereocilia. In these hair cells, MyoVIIA maintains stereocilia organization [6]. Severe mutations in the Drosophila MyoVIIA orthologue, crinkled (ck), are semi-lethal [7] and lead to...
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