Article
Life and death of proteins: a case study of glucose-starved Staphylococcus aureus.
Molecular & cellular proteomics : MCP - 1 Sept 2012
Michalik Stephan, Bernhardt Jörg, Otto Andreas, Moche Martin, Becher Dörte, Meyer Hanna, Lalk Michael, Schurmann Claudia, Schlüter Rabea, Kock Holger, Gerth Ulf, Hecker Michael
Abstract excerpt
The cellular amount of proteins not only depends on synthesis but also on degradation. Here, we expand the understanding of differential protein levels by complementing synthesis data with a proteome-wide, mass spectrometry-based stable isotope labeling with amino acids in cell culture analysis of protein degradation in the human pathogen Staphylococcus aureus during glucose starvation. Monitoring protein...
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