Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells.

BMC immunology - 16 Apr 2020

Beauford Samantha S, Kumari Anita, Garnett-Benson Charlie

Abstract excerpt

BACKGROUND: The use of immunotherapy strategies for the treatment of advanced cancer is rapidly increasing. Most immunotherapies rely on induction of CD8+ tumor-specific cytotoxic T cells that are capable of directly killing cancer cells. Tumors, however, utilize a variety of mechanisms that can suppress anti-tumor immunity. CD4+ regulatory T cells can directly inhibit cytotoxic T cell activity and these cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to CTLA-4 Antigen
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy

Share to Radiation, Ionizing

Share to T-Lymphocytes, Cytotoxic

Share to T-Lymphocytes, Regulatory

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 32299365
DOI: 10.1186/s12865-020-00349-w
PMCID: PMC7164225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells.PMID 32299365Read ↗

Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells.Semantic proximity Read ↗

Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer.Semantic proximity Read ↗

Immunomodulatory Effects of RadiotherapySemantic proximity Read ↗

Induced and natural regulatory T cells in human cancer.Semantic proximity Read ↗

The convergence of radiation and immunogenic cell death signaling pathwaysSemantic proximity Read ↗

Regulatory T Cells: An Emerging Player in Radiation-Induced Lung Injury.Semantic proximity Read ↗

Regulatory T cell targeting in cancer: Emerging strategies in immunotherapySemantic proximity Read ↗

The immunological consequences of radiation‐induced DNA damageSemantic proximity Read ↗

Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy.Semantic proximity Read ↗

Human CD4+CD25+ Regulatory T Cells Are Sensitive to Low Dose Cyclophosphamide: Implications for the Immune ResponseSemantic proximity Read ↗

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines.Semantic proximity Read ↗

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.