Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY

25 Feb 2019

Abstract excerpt

Significance Gastric cancer is the third leading cause of cancer deaths worldwide. Helicobacter pylori is a bacterium that infects the stomach of half of the human population, and 90% of gastric carcinoma cases are due to this infection. Antibiotic eradication has limited benefit in reducing cancer risk; new approaches are needed. We have implicated polyamines in gastric carcinogenesis. Until now,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori-related gastroenterology studies
Share to Parasitic Infections and Diagnostics
Share to Polyamine Metabolism and Applications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30804204
DOI: 10.1073/pnas.1814497116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagYPMID 30804204Read ↗

At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer.Semantic proximity Read ↗

At the bedside: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer.Semantic proximity Read ↗

Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer riskSemantic proximity Read ↗

N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pyloriSemantic proximity Read ↗

Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cellsSemantic proximity Read ↗

N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pyloriSemantic proximity Read ↗

Targeting Helicobacter pylori for antibacterial drug discovery with novel therapeuticsSemantic proximity Read ↗

Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus.Semantic proximity Read ↗

Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent mannerSemantic proximity Read ↗

Preclinical evaluation of the efficacy of α−Difluoromethylornithine and Sulindac against SARS-CoV-2 infectionSemantic proximity Read ↗

Helicobacter pylori salvages purines from extracellular host cell DNA utilizing the outer membrane-associated nuclease NucT.Semantic proximity Read ↗

Helicobacter pylori Infection Causes Characteristic DNA Damage Patterns in Human CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.