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Article

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.

The Journal of biological chemistry - 29 Oct 2004

Griffiths Gareth J, Koh Mei Yee, Brunton Valerie G, Cawthorne Christopher, Reeves Natalie A, Greaves Martin, Tilby Michael J, Pearson D Graham, Ottley Christopher J, Workman Paul, Frame Margaret C, Dive Caroline

Abstract excerpt

Tumor resistance to current drugs prevents curative treatment of human colon cancer. A pressing need for effective, tumor-specific chemotherapies exists. The non-receptor-tyrosine kinase c-Src is overexpressed in >70% of human colon cancers and represents a tractable drug target. KM12L4A human me...

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Identifiers

PMID: 15326164
DOI: 10.1074/jbc.M408550200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15326164-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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