Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.

doi:10.1161/CIRCULATIONAHA.112.091462

Article

Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.

Circulation - 5 Jun 2012

Edelstein Leonard C, Luna Elizabeth J, Gibson Ian B, Bray Molly, Jin Ying, Kondkar Altaf, Nagalla Srikanth, Hadjout-Rabi Nacima, Smith Tara C, Covarrubias Daniel, Jones Stephen N, Ahmad Firdos, Stolla Moritz, Kong Xianguo, Fang Zhiyou, Bergmeier Wolfgang, Shaw Chad, Leal Suzanne M, Bray Paul F

Abstract excerpt

BACKGROUND: High shear force critically regulates platelet adhesion and thrombus formation during ischemic vascular events. To identify genetic factors that influence platelet thrombus formation under high shear stress, we performed a genome-wide association study and confirmatory experiments in...

Topics

Adult
Black or African American
Animals
Blood Platelets
Cell Size
Female
Genome-Wide Association Study
Genotype
Humans
Male

Membrane Proteins

Mice

Mice, Inbred C57BL

Mice, Knockout

Microfilament Proteins

Middle Aged

Models, Animal

Platelet Adhesiveness

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