Article
Establishment of a Bernard-Soulier syndrome model in zebrafish.
Haematologica - 1 Jul 2022
Lin Qing, Zhou Riyang, Meng Panpan, Wu Liangliang, Yang Lian, Liu Wenyu, Wu Jiaye, Cheng Yuhuan, Shi Linjuan, Zhang Yiyue
Abstract excerpt
Platelets play an essential role in thrombosis and hemostasis. Abnormal hemostasis can cause spontaneous or severe post-traumatic bleeding. Bernard-Soulier syndrome (BSS) is a rare inherited bleeding disorder caused by a complete quantitative deficiency in the GPIb-IX-V complex. Multiple mutations in GP9 lead to the clinical manifestations of BSS. Understanding the roles and underlying mechanisms of GP9 in...
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