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Article

Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging.

Genetic epidemiology - 1 Jul 2012

Valdar William, Sabourin Jeremy, Nobel Andrew, Holmes Christopher C

Abstract excerpt

Significance testing one SNP at a time has proven useful for identifying genomic regions that harbor variants affecting human disease. But after an initial genome scan has identified a "hit region" of association, single-locus approaches can falter. Local linkage disequilibrium (LD) can make both the number of underlying true signals and their identities ambiguous. Simultaneous modeling of multiple loci should...

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Identifiers

PMID: 22549815
DOI: 10.1002/gepi.21639
PMCID: PMC3470705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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