Article
Multi-ethnic analysis reveals soluble L-selectin may be post-transcriptionally regulated by 3'UTR polymorphism: the Multi-Ethnic Study of Atherosclerosis (MESA).
Human genetics - 1 Apr 2015
Berardi Cecilia, Larson Nicholas B, Decker Paul A, Wassel Christina L, Kirsch Phillip S, Pankow James S, Sale Michele M, de Andrade Mariza, Sicotte Hugues, Tang Weihong, Hanson Naomi Q, Tsai Michael Y, Chen Yii-Der Ida, Bielinski Suzette J
Abstract excerpt
L-Selectin is constitutively expressed on leukocytes and mediates their interaction with endothelial cells during inflammation. Previous studies on the association of soluble L-selectin (sL-selectin) with cardiovascular disease (CVD) are inconsistent. Genetic variants associated with sL-selectin levels may be a better surrogate of levels over a lifetime. We explored the association of genetic variants and...
Topics
- 3' Untranslated Regions
- Aged
- Atherosclerosis
- Cohort Studies
- Ethnicity
- Female
- Gene Expression Regulation
- Genetic Association Studies
- Humans