Article
The genetic determinants of atorvastatin response.
Current opinion in molecular therapeutics - 1 Dec 2007
Rodrigues Alice C, Hirata Mário H, Hirata Rosario D C
Abstract excerpt
The statins or HMG-CoA reductase inhibitors are considered one of the most effective classes of drugs for reducing LDL and total cholesterol. Although, statin treatment has beneficial effects in the prevention of cardiovascular disease, considerable inter-individual variation exists in response to statin therapy, as well as in the incidence of adverse effects. Genetic factors contribute to patients'...
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