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Article

Evolution of the hepatitis E virus polyproline region: order from disorder.

Journal of virology - 1 Sept 2012

Purdy Michael A

Abstract excerpt

The hepatitis E virus (HEV) polyproline region (PPR) is an intrinsically unstructured region (IDR). This relaxed structure allows IDRs, which are implicated in the regulation of transcription and translation, to bind multiple ligands. Originally the nucleotide variability seen in the HEV PPR was assumed to be due to high rates of insertion and deletion. This study shows that the mutation rate is about the same in...

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Identifiers

PMID: 22811526
DOI: 10.1128/JVI.01374-12
PMCID: PMC3446631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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