Article
Identification of functional cis-acting RNA elements in the hepatitis E virus genome required for viral replication.
PLoS pathogens - 1 May 2020
Ju Xiaohui, Xiang Guangtao, Gong Mingli, Yang Rui, Qin Jierui, Li Yafei, Nan Yuchen, Yang Yonglin, Zhang Qiangfeng Cliff, Ding Qiang
Abstract excerpt
There are approximately 20 million events of hepatitis E virus (HEV) infection worldwide annually. The genome of HEV is a single-strand, positive-sense RNA containing 5' and 3' untranslated regions and three open reading frames (ORF). HEV genome has 5' cap and 3' poly(A) tail to mimic host mRNA to escape the host innate immune surveillance and utilize host translational machineries for viral protein translation....
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