Insertions and Duplications in the Polyproline Region of the Hepatitis E Virus

Abstract excerpt

Recombinant strains of hepatitis E virus (HEV) with insertions of human genomic fragments or HEV sequence duplications in the sequence encoding the polyproline region (PPR) were previously described in chronically infected patients. Such genomic rearrangements confer a replicative advantage in vitro but little is known about their frequency, location or origin. As the sequences of only a few virus genomes are...

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