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Article

Incorporation of transmembrane hydrophobic mutations in the TCR enhance its surface expression and T cell functional avidity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2012

Haga-Friedman Astar, Horovitz-Fried Miryam, Cohen Cyrille J

Abstract excerpt

TCR-gene transfer represents an effective way to redirect the specificity of T lymphocytes for therapeutic purposes. Recent successful clinical trials have underscored the potential of this approach in which efficient expression of the exogenous TCR has been directly linked to the efficacy of T cell activity. It has been also demonstrated that the TCR exhibits a lack of stability associated with the presence of...

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Identifiers

PMID: 22544927
DOI: 10.4049/jimmunol.1103020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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