Article
Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells.
Clinical immunology (Orlando, Fla.) - 1 May 2006
Scholten Kirsten B J, Kramer Duco, Kueter Esther W M, Graf Marcus, Schoedl Thomas, Meijer Chris J L M, Schreurs Marco W J, Hooijberg Erik
Abstract excerpt
Expression of native transgenic T cell receptors in recipient human T cells is often insufficient to achieve highly reactive T cell bulks. Here we show that codon modification of an HPV16E7-specific T cell receptor (TCR), together with omission of mRNA instability motifs and (cryptic) splice sites, leads to a dramatic increase in the expression levels of the transgenic TCRs in human CD8+ T cells. The...
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