Article
Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
The Journal of biological chemistry - 22 Jun 2012
Kammerer Robert, Rüttiger Lukas, Riesenberg Rainer, Schäuble Constanze, Krupar Rosemarie, Kamp Annegret, Sunami Kishiko, Eisenried Andreas, Hennenberg Martin, Grunert Fritz, Bress Andreas, Battaglia Sebastiano, Schrewe Heinrich, Knipper Marlies, Schneider Marlon R, Zimmermann Wolfgang
Abstract excerpt
The vertebrate-restricted carcinoembryonic antigen gene family evolves extremely rapidly. Among their widely expressed members, the mammal-specific, secreted CEACAM16 is exceptionally well conserved and specifically expressed in the inner ear. To elucidate a potential auditory function, we inacti...
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