Article
Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane.
Human molecular genetics - 15 May 2014
Legan P Kevin, Goodyear Richard J, Morín Matías, Mencia Angeles, Pollard Hilary, Olavarrieta Leticia, Korchagina Julia, Modamio-Hoybjor Silvia, Mayo Fernando, Moreno Felipe, Moreno-Pelayo Miguel-Angel, Richardson Guy P
Abstract excerpt
Tecta is a modular, non-collagenous protein of the tectorial membrane (TM), an extracellular matrix of the cochlea essential for normal hearing. Missense mutations in Tecta cause dominant forms of non-syndromic deafness and a genotype-phenotype correlation has been reported in humans, with mutations in different Tecta domains causing mid- or high-frequency hearing impairments that are either stable or...
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