Article
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 2000
Small G W, Ercoli L M, Silverman D H, Huang S C, Komo S, Bookheimer S Y, Lavretsky H, Miller K, Siddarth P, Rasgon N L, Mazziotta J C, Saxena S, Wu H M, Mega M S, Cummings J L, Saunders A M, Pericak-Vance M A, Roses A D, Barrio J R, Phelps M E
Abstract excerpt
The major known genetic risk for Alzheimer's disease (AD), apolipoprotein E-4 (APOE-4), is associated with lowered parietal, temporal, and posterior cingulate cerebral glucose metabolism in patients with a clinical diagnosis of AD. To determine cognitive and metabolic decline patterns according to genetic risk, we investigated cerebral metabolic rates by using positron emission tomography in middle-aged and older...
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