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Article

Autophagy and Ubiquitin-Proteasome System Coordinate to Regulate the Protein Quality Control of Neurodegenerative Disease-Associated DCTN1.

Neurotoxicity research - 1 Jan 2020

Wang Nana, Ma Qilian, Peng Panpan, Yu Yunhao, Xu Shiqiang, Wang Guanghui, Ying Zheng, Wang Hongfeng

Abstract excerpt

Motor neuron diseases are neurodegenerative diseases that are characterized by degeneration of the upper and lower motor neurons in the central nervous system. Mutations in Dynactin 1 (DCTN1), a component in the Dynein/Dynactin motor complex, have been previously identified to cause motor neuron diseases and other neurodegenerative disorders. Recent studies showed that motor neuron disease-linked mutation, such...

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PMID: 31654383
DOI: 10.1007/s12640-019-00113-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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