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Article

The role of chaperone-mediated autophagy in huntingtin degradation.

PloS one - 1 Jan 2012

Qi Lin, Zhang Xing-Ding, Wu Jun-Chao, Lin Fang, Wang Jin, DiFiglia Marian, Qin Zheng-Hong

Abstract excerpt

Huntington Disease (HD) is caused by an abnormal expansion of polyQ tract in the protein named huntingtin (Htt). HD pathology is featured by accumulation and aggregation of mutant Htt in striatal and cortical neurons. Aberrant Htt degradation is implicated in HD pathogenesis. The aim of this study was to investigate the regulatory role of chaperone-mediated autophagy (CMA) components, heat shock protein cognate...

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Identifiers

PMID: 23071649
DOI: 10.1371/journal.pone.0046834
PMCID: PMC3469570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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