Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple barriers to nonhomologous DNA end joining during meiosis in Drosophila.

Genetics - 1 Jul 2012

Joyce Eric F, Paul Anshu, Chen Katherine E, Tanneti Nikhila, McKim Kim S

Abstract excerpt

Repair of meiotic double-strand breaks (DSBs) uses the homolog and recombination to yield crossovers while alternative pathways such as nonhomologous end joining (NHEJ) are suppressed. Our results indicate that NHEJ is blocked at two steps of DSB repair during meiotic prophase: first by the activity of the MCM-like protein MEI-218, which is required for crossover formation, and, second, by Rad51-related proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to DNA-Binding Proteins
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA End-Joining Repair

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Egg Proteins

Share to Meiosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22542963
DOI: 10.1534/genetics.112.140996
PMCID: PMC3389970

Genes

SPN
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple barriers to nonhomologous DNA end joining during meiosis in Drosophila.PMID 22542963Read ↗

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks.Semantic proximity Read ↗

Interdependent and separable functions of <i>C. elegans</i> MRN-C complex members couple formation and repair of meiotic DSBsSemantic proximity Read ↗

Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates.Semantic proximity Read ↗

Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization.Semantic proximity Read ↗

Homologous recombinational repair proteins in mouse meiosisSemantic proximity Read ↗

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.Semantic proximity Read ↗

Single Holliday junctions are intermediates of meiotic recombination.Semantic proximity Read ↗

Loss of Drosophila Mei-41/ATR Alters Meiotic Crossover Patterning.Semantic proximity Read ↗

Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.Semantic proximity Read ↗

HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.Semantic proximity Read ↗

Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.Semantic proximity Read ↗

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.