Article
Genomic landscape of rat strain and substrain variation.
BMC genomics - 6 May 2015
Hermsen Roel, de Ligt Joep, Spee Wim, Blokzijl Francis, Schäfer Sebastian, Adami Eleonora, Boymans Sander, Flink Stephen, van Boxtel Ruben, van der Weide Robin H, Aitman Tim, Hübner Norbert, Simonis Marieke, Tabakoff Boris, Guryev Victor, Cuppen Edwin
Abstract excerpt
BACKGROUND: Since the completion of the rat reference genome in 2003, whole-genome sequencing data from more than 40 rat strains have become available. These data represent the broad range of strains that are used in rat research including commonly used substrains. Currently, this wealth of information cannot be used to its full extent, because the variety of different variant calling algorithms employed by...
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