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Article

Targeting Rad51 as a strategy for the treatment of melanoma cells resistant to MAPK pathway inhibition

2 Jul 2020

Abstract excerpt

Rad51 is an essential factor of the homologous recombination DNA repair pathway and therefore plays an important role in maintaining genomic stability. We show that RAD51 and other homologous recombination repair genes are overexpressed in metastatic melanoma cell lines and in melanoma patient samples, which correlates with reduced survival of melanoma patients. In addition, Rad51 expression in melanoma cells was...

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PMID: 32719412
DOI: 10.1038/s41419-020-2702-y

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