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Article

Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression.

The Journal of investigative dermatology - 1 Jan 2008

Kaufmann William K, Nevis Kathleen R, Qu Pingping, Ibrahim Joseph G, Zhou Tong, Zhou Yingchun, Simpson Dennis A, Helms-Deaton Jennifer, Cordeiro-Stone Marila, Moore Dominic T, Thomas Nancy E, Hao Honglin, Liu Zhi, Shields Janiel M, Scott Glynis A, Sharpless Norman E

Abstract excerpt

Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints that arrest growth and suppress genetic instability. NHMs displayed effective G1 and G2 checkpoint responses to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17597816
DOI: 10.1038/sj.jid.5700935
PMCID: PMC2753794

Genes

CDC7
DDB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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