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Article

A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma.

Pigment cell & melanoma research - 1 May 2016

Spoerri Loredana, Brooks Kelly, Chia KeeMing, Grossman Gavriel, Ellis Jonathan J, Dahmer-Heath Mareike, Škalamera Dubravka, Pavey Sandra, Burmeister Bryan, Gabrielli Brian

Abstract excerpt

Melanomas have high levels of genomic instability that can contribute to poor disease prognosis. Here, we report a novel defect of the ATM-dependent cell cycle checkpoint in melanoma cell lines that promotes genomic instability. In defective cells, ATM signalling to CHK2 is intact, but the cells are unable to maintain the cell cycle arrest due to elevated PLK1 driving recovery from the arrest. Reducing PLK1...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26854966
DOI: 10.1111/pcmr.12466

Genes

ATM
PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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