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Article

Fatty acid metabolism in patients with PPARgamma mutations.

The Journal of clinical endocrinology and metabolism - 1 Nov 2008

Tan Garry D, Savage David B, Fielding Barbara A, Collins Jenny, Hodson Leanne, Humphreys Sandy M, O'Rahilly Stephen, Chatterjee Krishna, Frayn Keith N, Karpe Fredrik

Abstract excerpt

CONTEXT: PPARG mutations may cause insulin resistance and dyslipidemia, but little is known about the mechanisms of the abnormalities of lipid metabolism. OBJECTIVE: We hypothesized that in PPARG mutations, abnormal adipose tissue triglyceride storage causes insulin resistance. DESIGN, PATIENTS, AND MAIN OUTCOME MEASURES: Whole-body and adipose tissue-specific metabolic phenotyping through arteriovenous blood...

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Topics

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Share to Fatty Acids, Nonesterified
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipodystrophy, Familial Partial

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Share to Pioglitazone

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Source

Identifiers

PMID: 18713822
DOI: 10.1210/jc.2007-2356

Genes

PPARG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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