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Article

Effects of mutations in the WD40 domain of α-COP on its interaction with the COPI coatomer in Saccharomyces cerevisiae.

Journal of microbiology (Seoul, Korea) - 1 Apr 2012

Kim Ki-Hyun, Kim Eun Kyung, Jeong Ki Young, Park Yun-Hee, Park Hee-Moon

Abstract excerpt

Replacement of glycine 227 in the fifth WD40 motif of α-COP/Ret1p/Soo1p by charged or aromatic amino acids is responsible for the temperature-dependent osmo-sensitivity of Saccharomyces cerevisiae, while truncations of WD40 motifs exerted a reduction in cell growth rate and impairment in assembly of cell-wall associated proteins such as enolase and Gas1p. Yeast two-hybrid analysis revealed that the ret1-1/soo1-1...

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PMID: 22538654
DOI: 10.1007/s12275-012-1326-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Effects of mutations in the WD40 domain of α-COP on its interaction with the COPI coatomer in Saccharomyces cerevisiae.PMID 22538654Read ↗

Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat.Semantic proximity Read ↗

Identification of a gene, SOO1, which complements osmo-sensitivity and defect in in vitro beta1,3-glucan synthase activity in Saccharomyces cerevisiae.Semantic proximity Read ↗

COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.Semantic proximity Read ↗

The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs.Semantic proximity Read ↗

Assembly, organization, and function of the COPII coatSemantic proximity Read ↗

Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic.Semantic proximity Read ↗

Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth.Semantic proximity Read ↗

epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP.Semantic proximity Read ↗

Identification and functional characterization of yeast zeta-COP.Semantic proximity Read ↗

C-terminal truncation of alpha-COP affects functioning of secretory organelles and calcium homeostasis in Hansenula polymorpha.Semantic proximity Read ↗

Cex1 is a component of the COPI intracellular trafficking machinery.Semantic proximity Read ↗

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