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Article

Activation of phenylalanine hydroxylase expression following genomic DNA transfection of hepatoma cells.

Differentiation; research in biological diversity - 1 Jul 1990

Faust D M, Imaizumi-Scherrer T, Fulchignoni-Lataud M C, Catherin A M, Iost I, Weiss M C

Abstract excerpt

Genomic DNA from cells producing the liver-specific enzyme phenylalanine hydroxylase (PAH) should contain, in active form, genes encoding regulators of PAH expression. We have transfected genomic DNA from PAH-producing rat hepatoma cells to PAH-deficient mouse hepatoma cells, and selected in tyro...

Topics

Animals
DNA, Neoplasm
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Genomic Library
Immunoblotting
Liver Neoplasms, Experimental
Nucleic Acid Hybridization
Phenotype
Phenylalanine Hydroxylase
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

RNA, Neoplasm

Rats

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 2253840
DOI: 10.1111/j.1432-0436.1990.tb00539.x

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2253840-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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