Article
Activation of phenylalanine hydroxylase expression following genomic DNA transfection of hepatoma cells.
Differentiation; research in biological diversity - 1 Jul 1990
Faust D M, Imaizumi-Scherrer T, Fulchignoni-Lataud M C, Catherin A M, Iost I, Weiss M C
Abstract excerpt
Genomic DNA from cells producing the liver-specific enzyme phenylalanine hydroxylase (PAH) should contain, in active form, genes encoding regulators of PAH expression. We have transfected genomic DNA from PAH-producing rat hepatoma cells to PAH-deficient mouse hepatoma cells, and selected in tyrosine-deficient medium for cells producing the enzyme. The frequency of colonies obtained was similar to that for...
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