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Article

β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.

The Journal of biological chemistry - 15 Jun 2012

Christian Whitney V, Li Na, Hinkle Patricia M, Ballatori Nazzareno

Abstract excerpt

The organic solute transporter, Ost/Slc51, is composed of two distinct proteins that must heterodimerize to generate transport activity, but the role of the individual subunits in mediating transport activity is unknown. The present study identified regions in Ostβ required for heterodimerization with Ostα, trafficking of the Ostα-Ostβ complex to the plasma membrane, and bile acid transport activity in HEK293...

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Identifiers

PMID: 22535958
DOI: 10.1074/jbc.M112.352245
PMCID: PMC3375545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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