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Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters

6 Apr 2004

Abstract excerpt

Slc22 family organic anion and cation transporters (OATs, OCTs, and OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. These proteins mediate the uptake or excretion of numerous physiologically (and pharmacologically) important compounds, and accordingly have been the focus of intensive study. Here we investigate the molecular phylogeny of the slc22 transporters, identifying homologs...

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PMID: 15054140
DOI: 10.1152/physiolgenomics.00014.2004

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