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Article

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation.

Oncotarget - 1 Apr 2012

Mathieu Véronique, Pirker Christine, Schmidt Wolfgang M, Spiegl-Kreinecker Sabine, Lötsch Daniela, Heffeter Petra, Hegedus Balazs, Grusch Michael, Kiss Robert, Berger Walter

Abstract excerpt

Melanoma is a devastating skin cancer characterized by distinct biological subtypes. Besides frequent mutations in growth- and survival-promoting genes like BRAF and NRAS, melanomas additionally harbor complex non-random genomic alterations. Using an integrative approach, we have analysed genomic and gene expression changes in human melanoma cell lines (N=32) derived from primary tumors and various metastatic...

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Source

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Identifiers

PMID: 22535842
DOI: 10.18632/oncotarget.473
PMCID: PMC3380575

Genes

BRAF
NRAS
SIPA1
AURKA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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