Article
Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2015
Garza Amanda E, Rariy Chevon M, Sun Bei, Williams Jonathan, Lasky-Su Jessica, Baudrand Rene, Yao Tham, Moize Burhanuddin, Hafiz Wan M, Romero Jose R, Adler Gail K, Ferri Claudio, Hopkins Paul N, Pojoga Luminita H, Williams Gordon H
Abstract excerpt
Striatin is a novel protein that interacts with steroid receptors and modifies rapid, nongenomic activity in vitro. We tested the hypothesis that striatin would in turn affect mineralocorticoid receptor function and consequently sodium, water, and blood pressure homeostasis in an animal model. We evaluated salt sensitivity of blood pressure in novel striatin heterozygote knockout mice. Compared with wild type,...
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