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Article

Multidimensional epistasis and fitness landscapes in enzyme evolution.

The Biochemical journal - 1 Jul 2012

Zhang Wei, Dourado Daniel F A R, Fernandes Pedro Alexandrino, Ramos Maria João, Mannervik Bengt

Abstract excerpt

The conventional analysis of enzyme evolution is to regard one single salient feature as a measure of fitness, expressed in a milieu exposing the possible selective advantage at a given time and location. Given that a single protein may serve more than one function, fitness should be assessed in several dimensions. In the present study we have explored individual mutational steps leading to a triple-point-mutated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22533640
DOI: 10.1042/BJ20120136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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