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Article

Directed enzyme evolution guided by multidimensional analysis of substrate-activity space.

Protein engineering, design & selection : PEDS - 1 Jan 2004

Larsson Anna-Karin, Emrén Lars O, Bardsley William G, Mannervik Bengt

Abstract excerpt

The directed evolution of protein function frequently involves identification of mutants with improved properties from a population of variants obtained by mutagenesis. The selection of clones to parent the subsequent generation is crucial to the continued creation of superior progeny. In the present study, multivariate analysis guided the evolution of human glutathione transferase (GST) T1-1 to 65-fold enhanced...

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Identifiers

PMID: 14985537
DOI: 10.1093/protein/gzh005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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