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"Multiagent" Screening Improves Directed Enzyme Evolution by Identifying Epistatic Mutations.

ACS synthetic biology - 20 May 2022

Yang Tian, Ye Zhixia, Lynch Michael D

Abstract excerpt

Enzyme evolution has enabled numerous advances in biotechnology and synthetic biology, yet still requires many iterative rounds of screening to identify optimal mutant sequences. This is due to the sparsity of the fitness landscape, which is caused by epistatic mutations that only offer improvements when combined with other mutations. We report an approach that incorporates diverse substrate analogues in the...

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PMID: 35507897
DOI: 10.1021/acssynbio.2c00136

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