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Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η

11 Nov 2020

Abstract excerpt

Nitrogen mustards are among the first modern anticancer chemotherapeutics that are still widely used as non-specific anticancer alkylating agents. While the mechanism of action of mustard drugs involves the generation of DNA interstrand cross-links, the predominant lesions produced by these drugs are nitrogen half-mustard-N7-dG (NHMG) adducts. The bulky major groove lesion NHMG, if left unrepaired, can be...

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PMID: 33175093
DOI: 10.1042/bcj20200767

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