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Article

The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history

26 May 2009

Abstract excerpt

BACKGROUND: Esophageal squamous cell carcinomas (ESCCs) tend to have multiple primary lesions, and it is believed that they arise from background mucosae with accumulation of genetic/epigenetic alterations. In this study, the objective was to elucidate the effects of smoking and drinking on the accumulation of epigenetic alterations in background mucosae. METHODS: Genes that are silenced in human ESCCs were...

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PMID: 19472401
DOI: 10.1002/cncr.24394

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