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Article

Generation of an actagardine A variant library through saturation mutagenesis.

Applied microbiology and biotechnology - 1 Sept 2012

Boakes Steven, Ayala Tania, Herman Mark, Appleyard Antony N, Dawson Michael J, Cortés Jesús

Abstract excerpt

The lantibiotic actagardine A is nineteen amino acids in length and comprises three intertwined C-terminal methyllanthionine-bridged rings and an N-terminal lanthionine-bridged ring. Produced by the actinomycete Actinoplanes garbadinensis ATCC 31049, actagardine A demonstrates antibacterial activity against important Gram-positive pathogens. This activity combined with its ribosomal synthesis makes it an...

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Identifiers

PMID: 22526797
DOI: 10.1007/s00253-012-4041-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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