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Article

Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection.

AIDS (London, England) - 17 Jul 2012

Sironi Manuela, Biasin Mara, Forni Diego, Cagliani Rachele, De Luca Mariacristina, Saulle Irma, Caputo Sergio Lo, Mazzotta Francesco, Macias Juan, Pineda Juan A, Caruz Antonio, Clerici Mario

Abstract excerpt

Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, single nucleotide polymorphisms frequency, or expression in HESN compared to controls, suggesting that, despite its central role in the HIV-1...

Read the complete abstract on PubMed

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Share to Disease Susceptibility
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

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Share to Immunity, Innate

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 22526516
DOI: 10.1097/QAD.0b013e328354b3c2

Genes

TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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